Endocrine Abstracts

Craniopharyngiomas (CF) - a benign tumor of the embryologic origin. The surgical method of treatment is the basic.Objective: to estimate incidence of hypogonatropic hypogonadism before and after surgical treatment of CF at different topographical variations, and after the preservation of the pituitary stalk. Methods: The research involved 79 patients older than 18 years (41 women and 38 men) with a mean age - 40 [17; 69] with a ver...

Thyrotropinoma (TSH-secreting pituitary adenomas, TSH-AG) are rare tumor of the pituitary (0.5–2% of all pituitary adenomas). Localization of the tumor with the appropriate neuroendocrine disorders has features in the clinic. This is due to the direct damage to the nucleus and structures of the pituitary with hypersecretion of TSH, which leads to overstimulation of the thyroid gland and the emergence of the clinical picture of ‘central’ hyperthyroidism. Differen...

A 32-year-old woman presented with primary amenorrhea, prolactin (PRL) level of 154150 mIU/l (40–530 mIU/l) diagnosed with an endo-supra-infra-laterosellar giant pituitary adenoma measuring maximum 6.2 cm. The patient was prescribed a treatment with cabergoline (CAB) at an initial dose of 0.5 mg per week. The treatment decreased the tumour size and brought to normal the level of PRL. After 7 months of CAB treatment menarche was achieved, after 12 months the patient became...

Objective: To study epileptic seizures in patients with large and giant prolactinomas.Patients and methods: The study group included 45 patients with large prolactinoma (more 36 mm in diameter) and 23 patients with giant prolactinoma (more than 60 mm in diameter). 55 men and 13 women aged 16–67 years (mean 39). Patients were followed by hormone measurements, magnetic resonance imaging (MRI), electroencephalogram (EEG) and endocrinological, psychopat...

Background: Hyponatremia is a relatively frequent and serious complication developed in patients with different neurosurgical pathology. The aim of the study was to identify the frequency of occurrence of hyponatremia in neurosurgical patients.Materials and methods: A retrospective analysis included 39479 patients operated in the Institute of Neurosurgery from January 2008 to December 2014.Results: 785 patients (2% of all operated ...

The problem of the influence of disturbances of Hyper- or Hyponatraemia is the most common disorder of body fluid and electrolyte balance encountered in clinical practice. Electrolyte disbalance affected on the formation of mental disorders, their structure and dynamics in the literature has not been sufficiently studied. Perhaps there are certain factors and patterns of the influence of hypo- and hypernatraemia on mental activity with various lesions of the brain, which requi...

Introduction: Pituitary carcinomas are extremely rare neoplasms and molecular events leading to malignant pituitary transformation are largely unknown.Case report: 36-year-old man turned to the clinic for visual and oculomotor disorders. A large endo-supra-latero(S)sellar tumor was found on MRI. There was also an increase in the level of ACTH in the blood (60,80 pmol/l (normal values 5–49)). The level of free cortisol in 24-hour urine was normal. En...

Introduction: The risk of pituitary apoplexy (PApopl) is up to 9.5%. In 80% of cases, it is the first manifestation of the disease.Material and methods: The study included 94 PApopl from 1 day up to 9 years. Conservative treatment was performed in 37 cases, and 59 were operated on including 14 giant posthemorrhagic cysts. The probability of resorption – it is possible in 85%, instead of cysts (the probability of resorption of ~ 15%). After 3 months,...

The article presents a case of permanent central diabetes insipidus (CDI) in a patient after severe traumatic brain injury (TBI) in traffic accident. A 16-year-old boy entered to a medical facility in the coma (6 points of Glasgow Coma scale (GCS)). Diagnosis: acute TBI; severe cerebral contusion; subarachnoid hemorrhage; depressed comminuted cranial vault fracture; basilar skull fracture; visceral contusion. CDI diagnosed three days after injury when polyuria and hypernatremi...

Presented case demonstrates a rare diencephalic pathology — adipsic diabetes insipidus (ADI) with severe hypernatremia in a 58-year-old woman after ttranssphenoidal removal of stalk intraventricular craniopharyngioma. ADI was diagnosed because of hypernatremia (150–155 mmol/l), polyuria (up to 4 liters per day) and absence of thirst. Normalization of wa- ter-electrolyte balance occurred on the background of desmopressin therapy and sufficient hydration in postoperati...